Dr. Antonio Spadano

Formazione

• • 29/12/1978 – MEDICINA E CHIRURGIA (PAVIA)
  • 30/12/1982 – EMATOLOGIA GENERALE (CHIETI GABRIELE D’ANNUNZIO) – Specializzazione

• Remission-induction, consolidation and maintenance therapy by AVA protocol in acute non lymphoblastic leukemia. Hematologica. 67, 230, 1982.
• Il nucleoside 9-(1,3 dihydroxy-2-proproxymetil) guanina nella terapia della corioretinite da CMV in un paziente con AIDS. AIDS e Sindromi correlate a cura di F. Aiuti, M. Moroni e F. Pocchiari. Monduzzi Editore pag. 375, Roma, maggio 1987
• Trattamento dell’Emofilia A e sindromi correlate con crioprecipitati di FVIII “virus inattivati” Panta Rei Volume VI, Fascicolo 3-4, 1987
• Cytogenetics and acute non lymphocytic leukemia. Ann Genet. 1987;30(1):39-46.PMID: 3498428
• Meaning of chromosome 6 aberrations in Ph’-positive chronic granulocytic leukemia. Haematologica. 1984 Nov-Dec;69(6):661-70.
• Rieve AK Chronic granulocytic leukemia with loss of Philadelphia chromosome and development of a Philadelphia negative diploid clone. Haematologica. 1984 May-Jun;69(3):321-9.
• Chromosome anomalies and Waldenström’s macroglobulinemia Pathologica. 1983 Nov-Dec;75(1040):861-6.
• Alpha heavy chain disease: report of two cases. Haematologica. 1985 Sep-Oct;70(5):431-6.
• Plasma exchange as intensive therapy in thrombotic thrombocytopenic purpura. Haematologica. 1985 May-Jun;70(3):225-31.
• Chromosome changes in 19 patients with Waldenström’s macroglobulinemia. Cancer Genet Cytogenet. 1987 Dec;29(2):261-9.
• Autologous blood stem cell transplantation as intensive consolidation therapy in hematological malignancies. Haematologica. 1990 Jan-Feb;75 Suppl 1:60-4.
• Cytogenetic survey of sixty-one patients with preleukemic syndrome including myeloproliferative and myelodysplastic diseases. Ann Genet. 1990;33(4):214-8.
• Randomized comparison of Ceftriaxone versus Ceftriaxone plus Amikacin for the empirical treatment of infections in patiens with altered host defense: microbiological and clinical evaluation. Experimental Chemioterapy 38: 420-427,1992.
• Randomized comparison of ceftriaxone vs ceftriaxone plus amikacin for the empirical treatment of infections in patients with altered host defense. Microbiological and clinical evaluation. Chemotherapy 1992;38:420-7.
• Autologous blood stem cell transplantation in malignant lymphoma: an Italian Cooperative Study. Leukemia and Lymphoma 1992;7(1):11-16.
• The result of various tratment in TTP; a report of 18 Episodes in 12 patients Transfus Sci 13: 91-971992
• Complex translocations of the Ph chromosome and Ph negative CML arise from similar mechanisms, as evidenced by FISH analysis. Cancer Genet Cytogenet. 1994 Dec;78(2):153-9.
• Leukemic evolution in three patients with myelodysplastic syndrome and unusual chromosome changes. Cancer Genet Cytogenet. 1992 Jul 15;61(2):162-4.
• Cytogenetic survey on 80 patients with acute non-lymphocytic leukemia”. Cancer Genet Cytogenet, 59: 45-50, 1992.
• Leukemic evolution in three patients with myelodisplastic syndrome and unusual chromosome changes”. Cancer Genet Cytogenet, 61:162-164, 1992.
• Complex translocation of the Ph chromosome and Ph negative CML arise from similar mechanisms as evidenced by FISH analysis. Cancer Genet Cytogenet, 78:153-159, 1994.
• p53 loss and point mutations are associated with suppression of apoptosis and progression of CML into myeloid blastic crisis. Cancer Genet Cytogenet, 1997 Oct 1;98(1):28-35
• Karyotype refinement in five patients with acute myeloid leukemia using spectral karyotyping. Haematologica. 2000 Nov;85(11):1219-21.
• Spectral karyotyping (SKY) refinement of a complex karyotype with t(20; 21) in a Ph-positive CML patient submitted to peripheral blood stem cell transplantation. Bone Marrow Transplant 2000, Vol 26, 1125-27.
• Preliminary Data of Phase I Clinical Trial with Autologous Cytokine Induced Killer cells in Patients with Advanced Malignancies. Blood 2003, 102, 11: p57b, 3933.
• Large volume leukapheresis with AMICUS cell separator in peripheral blood stem cell autologous transplant. Transfus Apher Sci. 2001 Feb;24(1):79-83.
• Karyotype refinement by multicolor fluorescence in situ hybridization analysis in 18 patients with acute lymphoblastic leukemia. Haematologica. 2002 Aug;87(8):888-9.
• Chromosome 11 rearrangements and specific MLL amplification revealed by spectral karyotyping in a patient with refractory anaemia with excess of blasts (RAEB). Br J Haematol. 2003 Sep;122(5):760-3.
• Survival of elderly patients with acute myeloid leukemia. Haematologica. 2004 Mar;89(3):296-302.
• Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia. Leukemia.2004 Jun;18(6):1122-6.
• Acquired haemophilia masked by heparin therapy. Int J Immunopathol Pharmacol. 2004 May-Aug;17(2):227-8.
• Impact of a new dosing regimen of epoetin alfa on quality of life and anemia in patients with low-risk myelodysplastic syndrome. Ann Hematol. 2005 Mar;84(3):167-76. Epub 2004 Nov 30.
• Long term remission in BCR/ABL positive AML-M6 patient treated with Imatinib Mesylate.. Leukemia Research, April 2007, 31(4):563-567 (pubblicato online il 14 agosto 2006).
• Leukemia. 2007 Nov;21(11):2373-5. Epub 2007 Jun 21.
• Portal venous thrombosis in a young patient with idiopathic myelofibrosis and intrahepatic extramedullary hematopoiesis: a difficult diagnosis, prognosis and management.
• Is JAK2V617F mutation absence a risk factor for bleeding in Essential Thrombocythemia? An analysis on 106 patients. Blood Transfusion. 2010 Jan;8(1):21-7
• GIMEMA Italian Myeloma Network Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. Lancet. 2010 Dec 18;376(9758):2075-85
• Tale of a Bacteraemia by Rhodococcus equi, With Concomitant Lung Mass: What Came First, the Chicken or The Egg? Mediterr J Hematol Infect Dis. 2011
• Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma. Blood. 2012 Jul 5;120(1):9-19
• TET2 mutations in Ph-negative myeloproliferative neoplasms: identification of three novel mutations and relationship with clinical and laboratory findings. Biomed Res Int. 2013;2013:929840

Competenze Linguistiche

• Italiano